Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …

Heat shock protein 90 (Hsp90) is a molecular chaperone involved in the maturation of a
plethora of substrates (“clients”), including protein kinases, transcription factors, and E3 …

The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …

Over the past fifteen years, we have unveiled a new mechanism by which cells achieve
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …

Enzymes within the de novo purine biosynthetic pathway spatially organize into dynamic
intracellular assemblies called purinosomes. The formation of purinosomes has been …

To meet their purine demand, cells activate the de novo purine biosynthetic pathway and
transiently cluster the pathway enzymes into metabolons called purinosomes. Recently, we …

HSP90 is critical for maintenance of the cellular proteostasis. In cancer cells, HSP90 also
becomes a nucleating site for the stabilization of multiprotein complexes including signaling …

Mitochondrial dysfunction is one of the basic hallmarks of cellular pathology in
neurodegenerative diseases. Since the metabolic activity of neurons is highly dependent on …

Fluctuations in nutrient and biomass availability, often as a result of disease, impart
metabolic challenges that must be overcome in order to sustain cell survival and promote …

The purinosome is a dynamic metabolic complex composed of enzymes responsible for de
novo purine biosynthesis, whose formation has been associated with elevated purine …