Division and transmission: malaria parasite development in the mosquito

DS Guttery, M Zeeshan, DJP Ferguson… - Annual Review of …, 2022 - annualreviews.org
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

In vitro production of cat-restricted Toxoplasma pre-sexual stages

AV Antunes, M Shahinas, C Swale, DC Farhat… - Nature, 2024 - nature.com
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely
uncharted owing to ethical concerns regarding the use of cats as model organisms …

CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact

T Ishizaki, S Hernandez, MS Paoletta… - Biochemical Society …, 2022 - portlandpress.com
The∼ 30 Mb genomes of the Plasmodium parasites that cause malaria each encode∼
5000 genes, but the functions of the majority remain unknown. This is due to a paucity of …

A transcriptional switch controls sex determination in Plasmodium falciparum

AR Gomes, A Marin-Menendez, SH Adjalley, C Bardy… - Nature, 2022 - nature.com
Sexual reproduction and meiotic sex are deeply rooted in the eukaryotic tree of life, but
mechanisms determining sex or mating types are extremely varied and are only well …

Transcriptional control of the Cryptosporidium life cycle

KA Walzer, J Tandel, JH Byerly, AM Daniels… - Nature, 2024 - nature.com
The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children,
and a cause and consequence of chronic malnutrition,. There are no vaccines and only …

Gene-by-gene screen of the unknown proteins encoded on Plasmodium falciparum chromosome 3

J Kimmel, M Schmitt, A Sinner, PWTC Jansen… - Cell Systems, 2023 - cell.com
Taxon-specific proteins are key determinants defining the biology of all organisms and
represent prime drug targets in pathogens. However, lacking comparability with proteins in …

The Plasmodium falciparum CCCH zinc finger protein MD3 regulates male gametocytogenesis through its interaction with RNA‐binding proteins

A Farrukh, JP Musabyimana, U Distler… - Molecular …, 2024 - Wiley Online Library
The transmission of malaria parasites to mosquitoes is dependent on the formation of
gametocytes. Once fully matured, gametocytes are able to transform into gametes in the …

ApiAP2 Gene‐Network Regulates Gametocytogenesis in Plasmodium Parasites

E Quansah, F Pappoe, J Shen, M Liu… - Cellular …, 2022 - Wiley Online Library
Malaria is a mosquito‐borne infectious disease, caused by unicellular Apicomplexan
protozoa of the genus Plasmodium. The sexual stage of Plasmodium is one of the most …

A single cell atlas of sexual development in Plasmodium falciparum

SK Dogga, JC Rop, J Cudini, E Farr, A Dara… - Science, 2024 - science.org
The developmental decision made by malaria parasites to become sexual underlies all
malaria transmission. Here, we describe a rich atlas of short-and long-read single-cell …

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

AV Antunes, M Shahinas, C Swale, DC Farhat… - BioRXiv, 2023 - biorxiv.org
Summary paragraph Sexual reproduction of Toxoplasma gondii, which is restricted to the
small intestine of felids, is sparsely documented, due to ethical concerns surrounding the …