MicroRNA dysregulation in epilepsy: from pathogenetic involvement to diagnostic biomarker and therapeutic agent development

J Wang, J Zhao - Frontiers in molecular neuroscience, 2021 - frontiersin.org
Epilepsy is the result of a group of transient abnormalities in brain function caused by an
abnormal, highly synchronized discharge of brain neurons. MicroRNA (miRNA) is a class of …

[HTML][HTML] Potential clinical and biochemical markers for the prediction of drug-resistant epilepsy: a literature review

ZQ Li, W Cao, HL Sun, X Wang, SM Li, XT Ran… - Neurobiology of …, 2022 - Elsevier
Drug resistance is a major challenge in the treatment of epilepsy. Drug-resistant epilepsy
(DRE) accounts for 30% of all cases of epilepsy and is a matter of great concern because of …

Aberrant expression of miRNAs in epilepsy

S Ghafouri-Fard, BM Hussen, A Abak, M Taheri… - Molecular biology …, 2022 - Springer
Epilepsy is manifested by intermittent convulsions and alterations in consciousness. This
disorder has serious effects on daily functions and physical and mental health of affected …

Transporter regulation in critical protective barriers: focus on brain and placenta

V Taggi, M Riera Romo, M Piquette-Miller… - Pharmaceutics, 2022 - mdpi.com
Drug transporters play an important role in the maintenance of chemical balance and
homeostasis in different tissues. In addition to their physiological functions, they are crucial …

The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis

G Xie, H Chen, C He, S Hu, X Xiao, Q Luo - Functional & Integrative …, 2023 - Springer
Epilepsy is a neurological disorder that impacts millions of people worldwide, and it is
characterized by the occurrence of recurrent seizures. The pathogenesis of epilepsy is …

An enriched environment reduces hippocampal inflammatory response and improves cognitive function in a mouse model of stroke

HY Zhou, YP Huai, X Jin, P Yan, XJ Tang… - Neural Regeneration …, 2022 - journals.lww.com
An enriched environment is used as a behavioral intervention therapy that applies sensory,
motor, and social stimulation, and has been used in basic and clinical research of various …

Non-coding RNAs: new biomarkers and therapeutic targets for temporal lobe epilepsy

I Manna, F Fortunato, S De Benedittis… - International Journal of …, 2022 - mdpi.com
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy; it is considered a
network disorder associated with structural changes. Incomplete knowledge of the …

RNA therapeutics for epilepsy: An emerging modality for drug discovery

SN Hansen, A Holm, S Kauppinen, H Klitgaard - Epilepsia, 2023 - Wiley Online Library
Drug discovery in epilepsy began with the finding of potassium bromide by Sir Charles
Locock in 1857. The following century witnessed the introduction of phenotypic screening …

Recent developments in diagnosis of epilepsy: scope of MicroRNA and technological advancements

R Bandopadhyay, T Singh, MM Ghoneim, S Alshehri… - Biology, 2021 - mdpi.com
Simple Summary Through epilepsy is one of the leading causes of poor mental health,
increased school dropout, and socioeconomic burden, yet the diagnosis remains a …

Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol's …

NS El-Sayed, S Elatrebi, R Said, HF Ibrahim… - Metabolic Brain …, 2022 - Springer
Cognitive impairment is considered as a typical feature of neurodegenerative diseases in
diabetes mellitus (DM). However, the exact link between cognitive dysfunction and diabetes …