Numerous neurodegenerative diseases result from altered ion channel function and
mutations. The intracellular redox status can significantly alter the gating characteristics of …

Heart failure is defined as a clinical syndrome consisting of key symptoms and is due to a
structural and/or functional alteration of the heart that results in increased intracardiac …

Exercise can improve the cardiovascular health. However, the mechanism contributing to its
beneficial effect on elderly patients with myocardial infarction is obscure. 20-month-old male …

Transfusion dependent β-thalassemia is a genetic blood disorder characterized by chronic
anaemia. Blood transfusion is lifesaving but comes at a cost. Iron overload emerges as a …

At present, there is no therapeutic approach available to reverse the progression of
pathological fibrosis and ventricle chamber stiffening. This study is designed to explore the …

Heart failure is associated with histone deacetylase (HDAC) regulation of gene expression,
the inhibition of which is thought to be beneficial for heart failure therapy. Here, we explored …

Cardiovascular diseases (CVD) persist as a prominent cause of mortality worldwide, with
oxidative stress constituting a pivotal contributory element. The oxidative modification of …

MicroRNAs (miRNAs) have been highlighted as key players in numerous diseases, and
accumulating evidence indicates that pathological expressions of miRNAs contribute to both …

Objective Myocardial infarction (MI)-induced cardiac dysfunction can be attenuated by
aerobic exercises. This study explored the mechanism of interval training (IT) regulating …

随着经济的发展, 心力衰竭(HF) 患者的死亡率仍持续增长. 导致HF 的病因众多,
其中表观遗传和基因表达异常成为了HF 的重要发病机制之一. N6-甲基腺苷(m6A) …