Epithelial Na+ channels (ENaCs) are members of the ENaC/degenerin family of ion
channels that evolved to respond to extracellular factors. In addition to being expressed in …

Robust in vitro lung models are required for risk assessment to measure key events leading
to respiratory diseases. Primary normal human bronchial epithelial cells (NHBE) represent a …

Protease-activated receptors (PARs) are members of a well-known family of transmembrane
G protein-coupled receptors (GPCRs). Four PARs have been identified to date, of which …

Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate
specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially …

Introduction Plasmin and its precursor, plasminogen, are detectable in urine from patients
with glomerular disease. Urinary plasmin (ogen) levels correlate with blood pressure (BP) …

The epithelial Na+ channel (ENaC) γ subunit is essential for homeostasis of Na+, K+, and
body fluid. Dual γ subunit cleavage before and after a short inhibitory tract allows …

Objective: The Dahl salt-sensitive rat is a well-established model of salt-sensitive
hypertension. The goal of this study was to assess the expression and activity of renal …

Severe cases of COVID-19 are characterized by development of acute respiratory distress
syndrome (ARDS). Water accumulation in the lungs is thought to occur as consequence of …

Salt homeostasis is maintained by tight control of Na+ filtration and reabsorption. In the distal
part of the nephron the ubiquitin protein ligase Nedd4-2 regulates membrane abundance …

Cysteine cathepsins are lysosomal enzymes expressed in the kidneys and other tissues,
and are involved in the maturation and breakdown of cellular proteins. They have been …