A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

A framework for understanding the functions of biomolecular condensates across scales

AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

Cellular functions of long noncoding RNAs

RW Yao, Y Wang, LL Chen - Nature cell biology, 2019 - nature.com
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation

T Yamazaki, S Souquere, T Chujo, S Kobelke… - Molecular cell, 2018 - cell.com
A class of long noncoding RNAs (lncRNAs) has architectural functions in nuclear body
construction; however, specific RNA domains dictating their architectural functions remain …

Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems

LZ Yang, Y Wang, SQ Li, RW Yao, PF Luan, H Wu… - Molecular cell, 2019 - cell.com
Visualizing the location and dynamics of RNAs in live cells is key to understanding their
function. Here, we identify two endonuclease-deficient, single-component programmable …

Paraspeckles: where long noncoding RNA meets phase separation

AH Fox, S Nakagawa, T Hirose, CS Bond - Trends in biochemical sciences, 2018 - cell.com
Long noncoding RNA (lncRNA) molecules are some of the newest and least understood
players in gene regulation. Hence, we need good model systems with well-defined RNA and …

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

S Wen, Y Wei, C Zen, W Xiong, Y Niu, Y Zhao - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most prevalent messenger RNA
modification in mammalian cells. However, the disease relevant function of m6A on specific …