Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease
MR Edwards, NW Bartlett, D Clarke, M Birrell… - Pharmacology & …, 2009 - Elsevier
Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of …
responsible for significant morbidity and mortality worldwide. While the importance of …
Mechanical ventilation–associated lung fibrosis in acute respiratory distress syndrome a significant contributor to poor outcome
NE Cabrera-Benitez, JG Laffey, M Parotto… - …, 2014 - pmc.ncbi.nlm.nih.gov
One of the most challenging problems in critical care medicine is the management of
patients with the acute respiratory distress syndrome. Increasing evidence from …
patients with the acute respiratory distress syndrome. Increasing evidence from …
New targets for drug development in asthma
Asthma is a chronic inflammatory disease that affects about 300 million people worldwide, a
total that is expected to rise to about 400 million over the next 15–20 years. Most asthmatic …
total that is expected to rise to about 400 million over the next 15–20 years. Most asthmatic …
Kinases as novel therapeutic targets in asthma and chronic obstructive pulmonary disease
PJ Barnes, C Page - Pharmacological Reviews, 2016 - Elsevier
Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …
Assessment of chemical coverage of kinome space and its implications for kinase drug discovery
More than 500 compounds chosen to represent kinase inhibitor space have been screened
against a panel of over 200 protein kinases. Significant results include the identification of …
against a panel of over 200 protein kinases. Significant results include the identification of …
TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional …
DL Clarke, RL Clifford, S Jindarat, D Proud… - Journal of Biological …, 2010 - ASBMB
Asthmatic airway smooth muscle (ASM) expresses interferon-γ-inducible protein-10
(CXCL10), a chemokine known to mediate mast cell migration into ASM bundles that has …
(CXCL10), a chemokine known to mediate mast cell migration into ASM bundles that has …
Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation
KA Steinbrecher, E Harmel-Laws… - The Journal of …, 2008 - journals.aai.org
NF-κB plays a central, proinflammatory role in chronic intestinal inflammation, yet recent
work suggests a predominantly protective function for this transcription factor group in some …
work suggests a predominantly protective function for this transcription factor group in some …
Host defenses against bacterial lower respiratory tract infection
Bacterial pneumonia continues to be a significant cause of morbidity and mortality
worldwide. Recent studies have shown that lung epithelia signal through pattern recognition …
worldwide. Recent studies have shown that lung epithelia signal through pattern recognition …
Inhibition of NF-κB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK
Acting via the glucocorticoid receptor (GR), glucocorticoids exert potent anti-inflammatory
effects partly by repressing inflammatory gene transcription occurring via factors such as NF …
effects partly by repressing inflammatory gene transcription occurring via factors such as NF …
The role of mitochondria and oxidative/antioxidative imbalance in pathobiology of chronic obstructive pulmonary disease
AJ Białas, P Sitarek… - Oxidative medicine …, 2016 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable
disease, characterized by persistent airflow limitation that is usually progressive and …
disease, characterized by persistent airflow limitation that is usually progressive and …