An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

K Saliminejad, HR Khorram Khorshid… - Journal of cellular …, 2019 - Wiley Online Library
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in
posttranscriptional regulation of gene expression. They are powerful regulators of various …

Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

W Liu, X Wang - Genome biology, 2019 - Springer
We perform a large-scale RNA sequencing study to experimentally identify genes that are
downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target …

Making a good egg: human oocyte health, aging, and in vitro development

EE Telfer, J Grosbois, YL Odey… - Physiological …, 2023 - journals.physiology.org
Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

The bioinformatics toolbox for circRNA discovery and analysis

L Chen, C Wang, H Sun, J Wang, Y Liang… - Briefings in …, 2021 - academic.oup.com
Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …

[HTML][HTML] Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration

S Jiang, G Tian, Z Yang, X Gao, F Wang, J Li, Z Tian… - Bioactive materials, 2021 - Elsevier
Articular cartilage defect repair is a problem that has long plagued clinicians. Although
mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they …

Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …

Circulating miRNA analysis for cancer diagnostics and therapy

L Valihrach, P Androvic, M Kubista - Molecular Aspects of Medicine, 2020 - Elsevier
Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

MirDIP 5.2: tissue context annotation and novel microRNA curation

AC Hauschild, C Pastrello, GKA Ekaputeri… - Nucleic Acids …, 2023 - academic.oup.com
MirDIP is a well-established database that aggregates microRNA-gene human interactions
from multiple databases to increase coverage, reduce bias, and improve usability by …

Highly sensitive and reliable detection of microRNA for clinically disease surveillance using SERS biosensor integrated with catalytic hairpin assembly amplification …

S Weng, D Lin, S Lai, H Tao, T Chen, M Peng… - Biosensors and …, 2022 - Elsevier
MicroRNAs (miRNAs) play an important regulatory role in several diseases, especially as a
class of promising biomarkers for cancer diagnosis and prognosis. Here, a biosensor based …