Importance The proportion of patients who develop long-term benzodiazepine use remains
controversial, as do the length of time before long-term use develops and the factors …

While evidence supports the benefits of medications for the treatment of chronic insomnia,
there is ongoing debate regarding their appropriate duration of use. A panel of sleep experts …

Objectives A clear definition of what we understand of high‐dose misuse or of a 'markedly
increased dose'(as stated by the DSM‐5) is important and past definitions may be …

Objective Mild cognitive impairment (MCI) is associated with increased memory problems
although the ability to complete daily life activities remains relatively intact. This study …

Objectives: Older adults commonly take benzodiazepines (BZDs) that may have long-term
adverse cognitive effects. We investigated whether BZD use was related to developing mild …

Benzodiazepines and carbamazepine are mental disorder treatment-related contaminants
of emerging concern (CECs) routinely detected in water bodies. Electrochemical oxidation …

Background Prolonged treatment of insomnia using benzodiazepine (BZD) receptor
agonists, including BZD and non-BZD hypnotic drugs, can cause drug dependence …

Objective To measure the incidence of long-term benzodiazepine receptor agonist (BZRA)
use among individuals with anxiety, mood and/or sleep disorders. To identify factors …

Objective Patients with chronic insomnia are prone to long-term use of hypnotics. Reported
risk factors include aging, female sex, and comorbid psychiatric disorders. However, most …

Purpose Despite being discouraged by guidelines, long-term use of benzodiazepines and
related Z-drugs (BZDR) remains frequent in the real-world. An improved understanding of …