Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp)
degradation are reviewed. The KP accounts for~ 95% of dietary Trp degradation, of which …

Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading
cause of maternal and prenatal morbidity. PE is associated with hypertension after week 20 …

Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is
discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp …

Tryptophan (Trp) requirements in pregnancy are several-fold:(1) the need for increased
protein synthesis by mother and for fetal growth and development;(2) serotonin (5-HT) for …

Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear.
We developed machine-learning models for early prediction of preeclampsia (first 16 weeks …

Kynurenine pathway is the main route of tryptophan metabolism and produces several
metabolites with various biologic properties. It has been uncovered that several …

Preeclampsia (PE) is a devastating disorder of pregnancy that affects up to 8% of pregnant
women in the United States. The diagnosis of PE is made by the presentation of new-onset …