Neuroprotection for treatment of glaucoma in adults

DF Sena, K Lindsley - Cochrane Database of Systematic …, 2017 - cochranelibrary.com
Background Glaucoma is a heterogeneous group of conditions involving progressive
damage to the optic nerve, deterioration of retinal ganglion cells, and ultimately visual field …

Neuroprotective agents in the management of glaucoma

C Nucci, A Martucci, C Giannini, LA Morrone, G Bagetta… - Eye, 2018 - nature.com
Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized
by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in …

Natural products: evidence for neuroprotection to be exploited in glaucoma

A Adornetto, L Rombolà, LA Morrone, C Nucci… - Nutrients, 2020 - mdpi.com
Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy
characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular …

Novel drug delivery systems fighting glaucoma: Formulation obstacles and solutions

O Rahić, A Tucak, N Omerović, M Sirbubalo, L Hindija… - Pharmaceutics, 2020 - mdpi.com
Glaucoma is considered to be one of the biggest health problems in the world. It is the main
cause of preventable blindness due to its asymptomatic nature in the early stages on the …

Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular Delivery

C Puglia, P Blasi, C Ostacolo, E Sommella… - Frontiers in …, 2018 - frontiersin.org
Nanostructured lipid carriers (NLCs) loaded with palmitoylethanolamide (PEA) were
formulated with the aim to enhance ocular bioavailability of PEA, particularly to the back of …

Nutritional supplementation in the treatment of glaucoma: A systematic review

E Loskutova, C O'Brien, I Loskutov, J Loughman - Survey of ophthalmology, 2019 - Elsevier
Current treatment strategies for glaucoma are limited to halting disease progression and do
not restore lost visual function. Intraocular pressure is the main risk factor for glaucoma, and …

Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential

ER Nestmann - Food Science & Nutrition, 2017 - Wiley Online Library
Palmitoylethanolamide (PEA) is a natural fatty acid amide found in a variety of foods, which
was initially identified in egg yolk. Micro PEA of defined particle size (0.5–10 μm) was …

Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial

M Khalaj, A Saghazadeh, E Shirazi… - Journal of psychiatric …, 2018 - Elsevier
Inflammation as well as glutamate excitotoxicity have been proposed to participate in the
propagation of autism. Palmitoylethanolamide (PEA) is an endocannabinoid proven to …

[PDF][PDF] Increased absorption of palmitoylethanolamide using a novel dispersion technology system (LipiSperse®)

D Briskey, AR Mallard, A Rao - J. Nutraceuticals Food Sci, 2020 - academia.edu
Title: A Pharmacokinetic study showing the increased absorption of palmitoylethanolamide
using LipiSperse®. Background: Palmitoylethanolamide (PEA) is a naturally occurring …

Seeing over the horizon–targeting the endocannabinoid system for the treatment of ocular disease

EA Cairns, JT Toguri, RF Porter… - Journal of Basic and …, 2016 - degruyter.com
The observation that marijuana reduces intraocular pressure was made by Hepler and
Frank in the 1970s. Since then, there has been a significant body of work investigating …