Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

This chapter addresses, from a molecular structural perspective gained from examination of
x‐ray crystallographic and biochemical data, the mechanisms by which GTP‐bound Gα …

A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to
specific effector target molecules. The G protein transducin, Gt, couples photon-activated …

The retinal cyclic guanosine 3′, 5′-monophosphate (cGMP) phosphodiesterase (PDE) is
a key regulator of phototransduction in the vertebrate visual system. PDE consists of a …

The G protein transducin has been an often-used model for biochemical, structural, and
mechanistic studies of G protein function. Experimental studies have been limited, however …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

As the molecular mechanisms of vertebrate phototransduction became increasingly clear in
the 1980s, a persistent problem was the discrepancy between the slow GTP hydrolysis …

The central effector of visual transduction in retinal rod photoreceptors, cGMP
phosphodiesterase (PDE6), is a catalytic heterodimer (αβ) to which low molecular weight …

The photoreceptor G-protein, transducin, belongs to the class of heterotrimeric GTP-binding
proteins that transfer information from activated seven-span membrane receptors to effector …

The cGMP phosphodiesterase (PDE) of retinal rods plays a central role in
phototransduction. Illumination leads to its activation by a rod G-protein (Gt, transducin), thus …