The critical shortage of organs available for renal transplantation has led to the
consideration of alternative strategies for increasing the donor pool. Recently, the cadaveric …

In the 30 years since the rabbit antithymocyte globulin (rATG) Thymoglobulin® was first
licensed, its use in solid organ transplantation and hematology has expanded progressively …

Background. The minimum sample size to perform a clinical trial aimed to modify the natural
history of chronic allograft nephropathy (CAN) is very large. Since the presence of chronic …

Glomerular number (N g) is considered a major determinant of renal function and outcome.
In the dog, it has been shown that Ng can be estimated with reasonable precision in vivo by …

The more than 25 years of clinical experience with rabbit antithymocyte globulin (rATG),
specifically Thymoglobulin®, has transformed immuno-suppression in solid organ …

The number of patients awaiting organ transplantation has progressively increased during
the last decade. Although the number of all registrants tripled during that time period only …

Background. To define the role of mammalian target of rapamycin inhibitors in kidney
transplantation, we compared efficacy and safety of two immunosuppressive regimens—a …

Kidney grafts from suboptimal donors are more likely to suffer the nephrotoxic side‐effects of
cyclosporine than kidneys from standard donors. In an attempt to avoid the use of …

Calcineurin inhibitor-related renal toxicity affects patient and graft survival in transplant
recipients. Our clinical experience has revealed sirolimus to be an effective agent in treating …

Background. There is an increasing tendency to allocate kidneys from marginal donors in
older recipients. This combination optimizes the uses of an expanded donor pool but …