Biotherapeutics are increasingly becoming the mainstay in the treatment of a variety of
human conditions, particularly in oncology and hematology. The production of therapeutic …

Protein synthesis from mRNA is an energy-intensive and tightly controlled cellular process.
Translation elongation is a well-coordinated, multifactorial step in translation that undergoes …

Ribosome profiling is a powerful technique used to study translation at the genome-wide
level, generating unique information concerning ribosome positions along RNAs. Optimal …

Ribosome stalling is manifested by the local accumulation of ribosomes at specific codon
positions of mRNAs. Here, we present ROSE, a deep learning framework to analyze high …

Accuracy and efficiency are fundamental to mRNA translation. Codon usage bias is
widespread across species. Despite the long-standing association between optimized …

Ribosome profiling (Ribo-seq) is a powerful technique for measuring protein translation;
however, sampling errors and biological biases are prevalent and poorly understood …

Ribosome profiling is emerging as a powerful technique that enables genome-wide
investigation of in vivo translation at sub-codon resolution. The increasing application of …

Abstract mRNA translation is carefully regulated at both the initiation and the elongation
step. Under heat stress, it is known that particular genes change their expression and …

Identifying the A-and P-site locations on ribosome-protected mRNA fragments from Ribo-
Seq experiments is a fundamental step in the quantitative analysis of transcriptome-wide …

Chloroplasts possess a considerably reduced genome that is decoded via an almost
minimal set of tRNAs. These features make an excellent platform for gaining insights into …