Late-stage C–H functionalization offers new opportunities in drug discovery

L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

New horizons for catalysis disclosed by supramolecular chemistry

G Olivo, G Capocasa, D Del Giudice… - Chemical Society …, 2021 - pubs.rsc.org
The adoption of a supramolecular approach in catalysis promises to address a number of
unmet challenges, ranging from activity (unlocking of novel reaction pathways) to selectivity …

A perspective on late-stage aromatic C–H bond functionalization

L Zhang, T Ritter - Journal of the American Chemical Society, 2022 - ACS Publications
Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

Radicals: reactive intermediates with translational potential

M Yan, JC Lo, JT Edwards… - Journal of the American …, 2016 - ACS Publications
This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

Nickel meets aryl thianthrenium salts: Ni (I)-catalyzed halogenation of arenes

S Ni, J Yan, S Tewari, EJ Reijerse, T Ritter… - Journal of the …, 2023 - ACS Publications
Herein, a regioselective, late-stage two-step arene halogenation method is reported. We
propose how unusual Ni (I)/(III) catalysis is enabled by a combination of aryl thianthrenium …

Synthetic organic electrochemistry: an enabling and innately sustainable method

EJ Horn, BR Rosen, PS Baran - ACS central science, 2016 - ACS Publications
While preparative electrolysis of organic molecules has been an active area of research
over the past century, modern synthetic chemists have generally been reluctant to adopt this …

Green chemistry meets medicinal chemistry: a perspective on modern metal-free late-stage functionalization reactions

JD Lasso, DJ Castillo-Pazos, CJ Li - Chemical Society Reviews, 2021 - pubs.rsc.org
The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …

Iron catalysis in organic synthesis: a critical assessment of what it takes to make this base metal a multitasking champion

A Fürstner - ACS Central Science, 2016 - ACS Publications
The current status of homogeneous iron catalysis in organic chemistry is contemplated, as
are the reasons why this particular research area only recently starts challenging the …

Cobalt-catalyzed C–H activation

M Moselage, J Li, L Ackermann - ACS Catalysis, 2016 - ACS Publications
Catalytic C–H activation has emerged as a powerful tool for sustainable syntheses. In the
recent years, notable success was achieved with the development of cobalt-catalyzed C–H …

Magnetically active iron oxide nanoparticles for catalysis of organic transformations: a review

P Kumar, V Tomar, D Kumar, RK Joshi, M Nemiwal - Tetrahedron, 2022 - Elsevier
Magnetic iron oxide nanoparticles (MIONPs) are an efficient retrievable catalytic system
recognized for their broad applications in numerous fields, including pharmaceutical …