MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets
MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the
post-transcriptional regulation of gene expression. They have been implicated in the …
post-transcriptional regulation of gene expression. They have been implicated in the …
Herpesviruses: harmonious pathogens but relevant cofactors in other diseases?
Most vertebrates are infected with one or more herpesviruses and remain so for the rest of
their lives. The relationship of immunocompetent healthy host with herpesviruses may …
their lives. The relationship of immunocompetent healthy host with herpesviruses may …
The role of microRNAs in the pathogenesis of herpesvirus infection
D Piedade, JM Azevedo-Pereira - Viruses, 2016 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs important in gene regulation. They are
able to regulate mRNA translation through base-pair complementarity. Cellular miRNAs …
able to regulate mRNA translation through base-pair complementarity. Cellular miRNAs …
miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6
S Wu, L He, Y Li, T Wang, L Feng, L Jiang, P Zhang… - Journal of Infection, 2013 - Elsevier
Objectives To investigate the role of miR-146a in dengue virus (DENV) replication. Methods
Expression levels of miR-146a were measured by real-time PCR and Northern blot. Role of …
Expression levels of miR-146a were measured by real-time PCR and Northern blot. Role of …
Circular RNA circDtx1 regulates IRF3-mediated antiviral immune responses through suppression of miR-15a-5p-dependent TRIF downregulation in teleost fish
W Zheng, Q Chu, L Yang, L Sun, T Xu - PLoS pathogens, 2021 - journals.plos.org
Circular RNAs (circRNAs) represent a class of widespread and diverse covalently closed
circular endogenous RNAs that exert crucial functions in regulating gene expression in …
circular endogenous RNAs that exert crucial functions in regulating gene expression in …
Identification of novel SARS-CoV-2 drug targets by host microRNAs and transcription factors co-regulatory interaction network analysis
Understanding the host regulatory mechanisms opposing virus infection and virulence can
provide actionable insights to identify novel therapeutics against severe acute respiratory …
provide actionable insights to identify novel therapeutics against severe acute respiratory …
The diverse roles of microRNAs at the host–virus interface
A Bernier, SM Sagan - Viruses, 2018 - mdpi.com
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-
transcriptional level. Through this activity, they are implicated in almost every cellular …
transcriptional level. Through this activity, they are implicated in almost every cellular …
A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency
D Pan, O Flores, JL Umbach, JM Pesola, P Bentley… - Cell host & …, 2014 - cell.com
After infecting peripheral sites, herpes simplex virus (HSV) invades the nervous system and
initiates latent infection in sensory neurons. Establishment and maintenance of HSV latency …
initiates latent infection in sensory neurons. Establishment and maintenance of HSV latency …
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
SZ Bahojb Mahdavi, A Jebelli… - Medicinal research …, 2024 - Wiley Online Library
Infections caused by viruses as the smallest infectious agents, pose a major threat to global
public health. Viral infections utilize different host mechanisms to facilitate their own …
public health. Viral infections utilize different host mechanisms to facilitate their own …
Mitochondria as pharmacological targets in Down syndrome
Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …
master regulators of cell life and death fate. Mitochondrial function integrates signalling …