Type I photosensitizers revitalizing photodynamic oncotherapy

D Chen, Q Xu, W Wang, J Shao, W Huang, X Dong - Small, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …

BINOL‐Based Chiral Macrocycles and Cages

Y Yu, Y Hu, C Ning, W Shi, A Yang… - Angewandte Chemie …, 2024 - Wiley Online Library
Chirality, a fundamental principle in chemistry, biology, and medicine, is prevalent in nature
and in organisms. Chiral molecules, such as DNA, RNA, and proteins, are crucial in …

Artificial biomolecular channels: enantioselective transmembrane transport of amino acids mediated by homochiral zirconium metal–organic cages

Y Li, J Dong, W Gong, X Tang, Y Liu… - Journal of the American …, 2021 - ACS Publications
Natural transport channels (or carriers), such as aquaporins, are a distinct type of
biomacromolecule capable of highly effective transmembrane transport of water or ions …

Stimulus-controlled anion binding and transport by synthetic receptors

J de Jong, JE Bos, SJ Wezenberg - Chemical Reviews, 2023 - ACS Publications
Anionic species are omnipresent and involved in many important biological processes. A
large number of artificial anion receptors has therefore been developed. Some of these are …

Artificial transmembrane ion transporters as potential therapeutics

J Yang, G Yu, JL Sessler, I Shin, PA Gale, F Huang - Chem, 2021 - cell.com
Various artificial transmembrane transporters, designed to function through mobile carrier or
channel mechanisms, have been developed in the past decade. With the aid of structural …

Photomodulation of transmembrane transport and potential by stiff-stilbene based bis (thio) ureas

SJ Wezenberg, LJ Chen, JE Bos… - Journal of the …, 2021 - ACS Publications
Membrane transport proteins fulfill important regulatory functions in biology with a common
trait being their ability to respond to stimuli in the environment. Various small-molecule …

Calix [4] pyrrole-based azo-bridged porous organic polymer for bromine capture

D Chen, D Luo, Y He, J Tian, Y Yu… - Journal of the …, 2022 - ACS Publications
The toxicity, corrosiveness, and volatility of elemental bromine presents challenges for its
safe storage and transportation. Purification from other halogens is also difficult. Here, we …

A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy

A Mondal, SN Save, S Sarkar, D Mondal… - Journal of the …, 2023 - ACS Publications
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …

A molecular anion pump

B Shao, H Fu, I Aprahamian - Science, 2024 - science.org
Pumping ions against a concentration gradient through protein-based transporters is a
cornerstone of numerous biological processes. Mimicking this function by using artificial …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …