Highlights•Calcium homeostasis is crucial in cancer, regulating many physiological
processes.•Calcium ion-related channels are crucial in cancer regulation and potential …

Osteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a
bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) …

Background: The expression of the transient receptor potential 1 (TRPA1) gene is increased
in many solid tumours, and its function relates to inflammation, oxidative stress or the …

Colorectal cancer is a cancer that arises from the abnormal growth of cells in the colon or
rectum. Osteosarcoma (OS) is a common primary bone tumor with high degree of …

The burden of cancer is growing in almost every country. Bone metastases significantly
affect the prognosis and lead to an increase in mortality and morbidity. The management of …

4. Aims This dissertation includes three different studies where commonly used in vitro cell-
based assays were applied to examine and understand the complex mechanisms behind …