Breast cancer is one of the most frequent cancer types worldwide and the first cause of
cancer-related deaths in women. Although significant therapeutic advances have been …

Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-
excitatory cells where they mediate significant store-operated calcium entry (SOCE), an …

Macrophages clear pathogens by phagocytosis and lysosomes that fuse with phagosomes
are traditionally regarded as to a source of membranes and luminal degradative enzymes …

Orai1 plays a major role in store-operated Ca2+ entry (SOCE) in triple-negative breast
cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein …

Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series
of dermatologic diseases. A large variety of biological events and bioactive molecules are …

Multiple families of Ca 2+-permeable channels co-exist on lysosomal Ca 2+ stores but how
each family couples to its own unique downstream physiology is unclear. We have therefore …

Calcium (Ca2+) signaling plays a dichotomous role in cellular biology, controlling cell
survival and proliferation on the one hand and cellular toxicity and cell death on the other …

The process of wound healing is intricate and tightly controlled, involving a number of
different cellular and molecular processes. Numerous cellular functions, especially those …

Glutamate N‐methyl‐D‐aspartate (NMDA) receptor (NMDAR) is critical for
neurotransmission as a Ca2+ channel. Nonetheless, flux‐independent signaling has also …

Astrocytes, once thought to be passive cells merely filling the space between neurons in the
nervous system, are receiving attention as active modulators of the brain and spinal cord …