T cells undergo positive and negative selection in the thymic cortex and medulla,
respectively. A promiscuous expression of a wide array of self-antigens in the thymus is …

The neocortex is the part of the brain responsible for execution of higher-order brain
functions, including cognition, sensory perception, and sophisticated motor control. During …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration
of corticospinal axons and restore forelimb function after spinal cord injury; however, the …

The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with
either positive or negative valence, but how it processes motivationally opposing information …

Self-tolerance to immune reactions is established via promiscuous expression of tissue-
restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), leading to the …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

RNA is a central and universal mediator of genetic information underlying the diversity of cell
types and cell states, which together shape tissue organization and organismal function …