Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

Age-related macular degeneration (AMD) is directly attributable to vision loss, posing
significant pressure on public health. AMD is recognized to be a multi-factorial disease and …

Age-related macular degeneration (AMD) remains a major cause of legal blindness, and
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …

One of the strongest susceptibility genes for age-related macular degeneration (AMD) is
complement factor H (CFH); however, its impact on AMD pathobiology remains unresolved …

Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …

Data from human dry and wet age-related macular degeneration (AMD) eyes support the
hypothesis that constant 'tickover'of the alternative complement pathway results in chronic …

High fat diets (HFD) have been utilized in rodent models of visual disease for over 50 years
to model the effects of lipids, metabolic dysfunction, and diet-induced obesity on vision and …

The mechanisms that connect complement system activation and basal deposit formation in
early stages of age-related macular degeneration (AMD) are insufficiently understood, which …

Age-related macular degeneration (AMD) is a leading cause of visual impairment of the
elderly population. Since AMD is a multifactorial age-related disease with various genetic …

Modeling complex eye diseases like age-related macular degeneration (AMD) and
glaucoma poses significant challenges, since these conditions depend highly on age …