Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation

SB Raut, PA Marathe, L van Eijk, R Eri… - Pharmacology & …, 2022 - Elsevier
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …

Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: a systematic review and meta-analysis …

KH Walsh, RK Das, ME Saladin, SK Kamboj - Psychopharmacology, 2018 - Springer
Background Consolidated memories can undergo enduring modification through retrieval-
dependent treatments that modulate reconsolidation. This represents a potentially …

The evidence for and against reactivation-induced memory updating in humans and nonhuman animals

KH Jardine, AE Huff, CE Wideman, SD McGraw… - Neuroscience & …, 2022 - Elsevier
Systematic investigation of reactivation-induced memory updating began in the 1960s, and
a wave of research in this area followed the seminal articulation of “reconsolidation” theory …

Involvement of classical neurotransmitter systems in memory reconsolidation: Focus on destabilization

CE Wideman, KH Jardine, BD Winters - Neurobiology of learning and …, 2018 - Elsevier
When consolidated long-term memories are reactivated they can destabilize, rendering the
memory labile and vulnerable to modification. This period of lability is followed by …

Destabilizing different strengths of fear memories requires different degrees of prediction error during retrieval

W Chen, J Li, L Xu, S Zhao, M Fan… - Frontiers in behavioral …, 2021 - frontiersin.org
Reactivation of consolidated memories can induce a labile period, in which these
reactivated memories might be susceptible to change and need reconsolidation. Prediction …

Treatment of adjustment disorder stemming from romantic betrayal using memory reactivation under propranolol: A open-label interrupted time series trial

M Lonergan, D Saumier, S Pigeon, PE Etienne… - Journal of Affective …, 2022 - Elsevier
Objectives In a sustained relationship, romantic betrayal is a catastrophic event that can
precipitate an adjustment disorder (AD). Surprisingly, there exists no empirically validated …

Lack of effect of propranolol on the reconsolidation of conditioned fear memory due to a failure to engage memory destabilisation

F Rotondo, K Biddle, J Chen, J Ferencik, M d'Esneval… - Neuroscience, 2022 - Elsevier
The prospect of exploiting memory reconsolidation to treat mental health disorders has
received great research interest, particularly following demonstrations that the β-adrenergic …

Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction

Z Dai, Y Liu, L Nie, W Chen, X Xu, Y Li… - …, 2023 - nature.com
Extinction training during the reconsolidation window following memory recall is an effective
behavioral pattern for promoting the extinction of pathological memory. However, promoted …

Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

J Machado Batista Sohn, NC Cardoso… - Scientific Reports, 2023 - nature.com
Abstract Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus
(DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and …

The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder

Z Dai, X Xu, W Chen, L Nie, Y Liu, N Sui… - Current Addiction …, 2022 - Springer
Purpose of the review The abuse of opioids induces many terrible problems in human health
and social stability. For opioid-dependent individuals, withdrawal memory can be …