Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

Intracellular and extracellular interactions with proteins enables the functional and
mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described …

Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors improve cardiovascular outcomes
in diverse patient populations, but their mechanism of action requires further study. The aim …

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …

Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

Obesity is a significant risk factor for arrhythmic cardiovascular death. Interactions between
epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the …

Diabetes is associated with increased incidence of heart failure even after controlling for
coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become …

Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and
lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and …

The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …