Communicating clocks shape circadian homeostasis
KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
Interplay between circadian clock and cancer: new frontiers for cancer treatment
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …
specific gene expression rhythms and how these depend on age and sex is not defined in …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Circadian rhythms, disease and chronotherapy
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism
The circadian clock and associated feeding rhythms have a profound impact on metabolism
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …
Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms
The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …
expression in the liver. To further dissect the respective contributions of feeding and the …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
Circadian etiology of type 2 diabetes mellitus
N Javeed, AV Matveyenko - Physiology, 2018 - journals.physiology.org
The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …
The circadian clock and liver function in health and disease
Each day, all organisms are subjected to changes in light intensity because of the Earth's
rotation around its own axis. To anticipate this geo-physical variability, and to appropriately …
rotation around its own axis. To anticipate this geo-physical variability, and to appropriately …