Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor …

Simple Summary Colorectal cancer (CRC) is very common throughout the world. Despite an
improved outcome with the current treatment regimen, a huge number of patients relapse …

Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with
chemotherapy is effective for patients with RAS wild type metastatic colorectal cancer …

Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Simple Summary Chemotherapy, radiotherapy and molecularly targeted therapy could
improve the prognosis of colorectal cancer (CRC) patients. Recently, immunotherapy …

Evidence has emerged in the last two decades that at the molecular level most chronic
diseases, including cancer, are caused by a dysregulated inflammatory response. The …

STAT3 is constitutively activated in colon cancer but its contributions in cancer-initiating cells
have not been explored. In this study, we characterized STAT3 in aldehyde dehydrogenase …

Abnormalities in the STAT3 pathway are involved in the oncogenesis of several cancers.
However, the mechanism by which dysregulated STAT3 signaling contributes to the …

MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which
were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of …

It is known that the signal transducer and activator of transcription 3 (STAT3) is a key
signaling molecule implicated in the regulation of growth and malignant transformation …