Purpose The purpose of the study is to assess the global risk of extracolonic secondary
primary cancers (SPCs) in patients with colorectal cancer (CRC). Methods Studies of SPC in …

Background Cancer survivors are at risk of developing second and subsequent primary
cancers, referred to as multiple primary cancers (MPCs). It is not clear whether the risk of …

Glutathione peroxidase 2 (Gpx-2) is a selenoenzyme with antioxidant capabilities that may
play a role in cancer development. Hence, we investigated the immunohistochemical …

With improvements in survival after colorectal cancer (CRC), more survivors are at risk of
developing a second cancer, particularly in younger populations where CRC incidence is …

Introduction Because of the improved colorectal cancer (CRC) survival in the US, patients
may live long enough after CRC diagnosis to the point where non–cancer-related …

With an increasing trend of patients with young‐onset colorectal cancer (CRC), risks of
second primary cancers (SPCs) among them become a concerning issue. We aimed to …

Background and aims This study aimed to investigate the incidence and the risk factors of
incidence for second primary malignancies (SPMs) onset among survivors diagnosed with …

BACKGROUND: The risk of a second primary cancer has increased along with the
increasing life expectancies of colorectal cancer survivors. OBJECTIVE: We aimed to …

Introduction A history of colorectal cancer (CRC) increases the risk of subsequent
gastrointestinal (GI) cancer. Cancers of the right colon, left colon, and rectum differ according …

Background While overall colorectal cancer (CRC) rates in the USA are declining, the
incidence of early-onset CRC (eoCRC) under age 50 is increasing. The aim of this study …