The complex aetiology of cerebral palsy

SJ Korzeniewski, J Slaughter, M Lenski… - Nature Reviews …, 2018 - nature.com
Cerebral palsy (CP) is the most prevalent, severe and costly motor disability of childhood.
Consequently, CP is a public health priority for prevention, but its aetiology has proved …

Maternal immune activation and abnormal brain development across CNS disorders

I Knuesel, L Chicha, M Britschgi, SA Schobel… - Nature Reviews …, 2014 - nature.com
Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Genetic insights into the causes and classification of the cerebral palsies

A Moreno-De-Luca, DH Ledbetter, CL Martin - The lancet neurology, 2012 - thelancet.com
Cerebral palsy—the most common physical disability of childhood—is a clinical diagnosis
encompassing a heterogeneous group of neurodevelopmental disorders that cause …

In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy

N Li, P Zhou, H Tang, L He, X Fang, J Zhao, X Wang… - Brain, 2022 - academic.oup.com
Cerebral palsy is the most prevalent physical disability in children; however, its inherent
molecular mechanisms remain unclear. In the present study, we performed in-depth clinical …

Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews

E Shepherd, RA Salam, P Middleton… - Cochrane Database …, 2017 - cochranelibrary.com
Background Cerebral palsy is an umbrella term encompassing disorders of movement and
posture, attributed to non‐progressive disturbances occurring in the developing fetal or …

Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews

E Shepherd, RA Salam, P Middleton… - Cochrane Database …, 2018 - cochranelibrary.com
Background Cerebral palsy is an umbrella term that encompasses disorders of movement
and posture attributed to non‐progressive disturbances occurring in the developing foetal or …

Glutamate transport and preterm brain injury

S Pregnolato, E Chakkarapani, AR Isles… - Frontiers in …, 2019 - frontiersin.org
Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

Cytokines and neurodevelopmental outcomes in extremely low birth weight infants

WA Carlo, SA McDonald, JE Tyson, BJ Stoll… - The Journal of …, 2011 - Elsevier
OBJECTIVE: To determine if selected pro-inflammatory and anti-inflammatory cytokines
and/or mediators of inflammation reported to be related to the development of cerebral palsy …

Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation

N Mohandas, S Bass-Stringer, J Maksimovic… - Clinical …, 2018 - Springer
Background Cerebral palsy (CP) is a clinical description for a group of motor disorders that
are heterogeneous with respect to causes, symptoms and severity. A diagnosis of CP cannot …

Rare copy number variation in cerebral palsy

G McMichael, S Girirajan, A Moreno-De-Luca… - European Journal of …, 2014 - nature.com
Recent studies have established the role of rare copy number variants (CNVs) in several
neurological disorders but the contribution of rare CNVs to cerebral palsy (CP) is not known …