Efficient targeted control of splicing is a major goal of functional genomics and therapeutic
applications. Guide (g) RNA-directed, deactivated (d) Cas CRISPR enzymes fused to …

Over the past decades, the proteomics field has undergone rapid growth. Progress in mass
spectrometry and bioinformatics, together with separation methods, has brought many …

Human pre-mRNA splicing requires the removal of introns with highly variable lengths, from
tens to over a million nucleotides. Therefore, mechanisms of intron recognition and splicing …