Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of
disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an …

Current pharmacological treatments for depression fail to produce adequate remission in a
significant proportion of patients. Increasingly, other systems, such as the microbiome–gut …

Rosmarinic acid (RA), a natural phenolic acid compound with a variety of bioactive
properties. However, the antidepressant activity and mechanism of RA remain unclear. The …

Over the past decade, ketamine, an NMDA receptor antagonist, has demonstrated fast-
acting antidepressant effects previously unseen with monoaminergic-based therapeutics …

Reelin, an extracellular matrix protein with putative antidepressant-like properties, becomes
dysregulated by chronic stress. Improvement in cognitive dysfunction and depression-like …

Alzheimer's disease (AD) accounts for most dementia cases, but we lack a complete
understanding of the mechanisms responsible for the core pathology associated with the …

Introduction Treatment with the synaptic plasticity protein reelin has rapid antidepressant-
like effects in adult corticosterone (CORT)-induced depressed rats, whether administered …

Novel antidepressants are predominantly evaluated preclinically in rodent models of chronic
stress in which animals experience a single prolonged exposure to chronic stress prior to …

Repeated exposure to the stress hormone corticosterone results in depressive-like
behaviours paralleled by the downregulation of hippocampal reelin expression. Reelin is …

Mood disorders mainly affect the patient's daily life, lead to suffering and disability, increase
the incidence rate of many medical illnesses, and even cause a trend of suicide. The …