Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Repurposing approved non-antitumor drugs is a promising and affordable strategy in drug
discovery to identify new therapeutic uses different from the original medical indication that …

Simple Summary Although non-prescription anthelmintics are often used for cancer
treatment, there is a lack of information regarding their anti-cancer effects in clinical settings …

Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are
associated with cancer initiation, growth, and response to therapies. As concentrations …

Lung cancer is a complex and heterogeneous disease, which has been associated with
various molecular alterations, including the overexpression and mutations of the epidermal …

Out of several heterocyclic templates, the use of a Benzimidazole (BZ) scaffold is immensely
observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd …

Simple Summary Exploring the possibility of using well-known marketed drugs in new
therapeutic indications, commonly known as drug repurposing, offers certain advantages …

Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …

In this study, we aimed to evaluate the anticancer effect of benzimidazole derivatives on
triple-negative breast cancer (TNBC) and investigate its underlying mechanism of action …