Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …

Mismatched base pairs are generated by damage to DNA, by damage to nucleotide
precursors, by errors that occur during DNA replication, and during the formation of …

The present invention relates to the detection of nucleic acid sequence differences using
coupled ligase detection reaction and polymerase chain reaction. One aspect of the present …

Alterations of the human MSH2 gene, a homologue of the bacterial MutS mismatch repair
gene, co–segregate with the majority of hereditary non–polyposis colon cancer (HNPCC) …

Microsatellite instability has been reported to be an important feature of tumors from
hereditary nonpolyposis colorectal carcinoma (HNPCC) patients. The recent discovery of …

Cancer of the bladder shows divergent clinical behaviour following diagnosis and it has
been proposed that two major groups of tumours exist that develop via different molecular …

DNA mismatch repair is an important pathway of mutation avoidance. It also contributes to
the cytotoxic effects of some kinds of DNA damage, and cells defective in mismatch repair …

WO 92/10588 6/1992 (EP). O 601714 A1 6/1994 (EP). WO 89/10977 11/1989 (WO). WO
90/15070 12/1990 (WO). WO 92/16655 10/1992 (WO). WO 93/17126 9/1993 (WO). WO …

BACKGROUND Microsatellite instability (MIN) has been identified in a wide variety of
human tumors, both familial and sporadic. In this study the authors attempted to correlate …

CONTEXT: The data describing the urologic extracolonic cancers associated with hereditary
nonpolyposis colorectal cancer (HNPCC) are variable. OBJECTIVE: Provide an update …