Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics

C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …

[HTML][HTML] Corneal regeneration strategies: from stem cell therapy to tissue engineered stem cell scaffolds

M Wang, Y Li, H Wang, M Li, X Wang, R Liu… - Biomedicine & …, 2023 - Elsevier
Corneal epithelial defects and excessive wound healing might lead to severe complications.
As stem cells can self-renew infinitely, they are a promising solution for regenerating the …

Current and emerging therapies for limbal stem cell deficiency

AM Elhusseiny, M Soleimani, TK Eleiwa… - Stem cells …, 2022 - academic.oup.com
The corneal epithelium serves to protect the underlying cornea from the external
environment and is essential for corneal transparency and optimal visual function …

Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery

M Soleimani, A Masoumi, B Momenaei… - Expert opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Mesenchymal stem cells (MSCs) are novel, promising agents for
treating ocular surface disorders. MSCs can be isolated from several tissues and delivered …

Cryopreservation does not change the performance and characteristics of allogenic mesenchymal stem cells highly over-expressing a cytoplasmic therapeutic …

YK Ho, KM Loke, JY Woo, YL Lee, HP Too - Stem Cell Research & …, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) driven gene directed enzyme prodrug
therapy is a promising approach to deliver therapeutic agents to target heterogenous solid …

Intrastromal versus subconjunctival injection of mesenchymal stem/stromal cells for promoting corneal repair

M Soleimani, R Mirshahi, K Cheraqpour… - The Ocular Surface, 2023 - Elsevier
Purpose Different approaches to delivery of mesenchymal stem/stromal cells (MSCs) for
ameliorating corneal injuries have been investigated. This study was aimed to compare the …

Corneal stem cells niche and homeostasis impacts in regenerative medicine; concise review

F Tavakkoli, TK Eleiwa, AM Elhusseiny… - European journal of …, 2023 - journals.sagepub.com
The limbal stem cells niche (LSCN) is an optimal microenvironment that provides the limbal
epithelial stem cells (LESCs) and strictly regulates their proliferation and differentiation …

Preclinical short-term and long-term safety of human bone marrow mesenchymal stem cells

Z Liang, G Zhang, GT Gan, D Naren, X Liu… - Cell …, 2023 - journals.sagepub.com
Mesenchymal stem cells (MSCs) have become a promising therapeutic method. More safety
data are needed to support clinical studies in more diseases. The aim of this study was to …

Pre-clinical evaluation of efficacy and safety of human limbus-derived stromal/mesenchymal stem cells with and without alginate encapsulation for future clinical …

M Damala, A Sahoo, N Pakalapati, V Singh, S Basu - Cells, 2023 - mdpi.com
Corneal opacification or scarring is one of the leading causes of blindness worldwide.
Human limbus-derived stromal/mesenchymal stem cells (hLMSCs) have the potential of …

Perspectives and Limitations of Mesenchymal Stem Cell–Based Therapy for Corneal Injuries and Retinal Diseases

B Hermankova, E Javorkova, K Palacka… - Cell …, 2025 - journals.sagepub.com
The eye represents a highly specialized organ, with its main function being to convert light
signals into electrical impulses. Any damage or disease of the eye induces a local …