The B7/CD28 families of immune checkpoints play vital roles in negatively or positively
regulating immune cells in homeostasis and various diseases. Recent basic and clinical …

Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …

Background T cells and natural killer (NK) cells are essential components of the immune
system and are regulated by coinhibitory and costimulatory molecules in which the B7 family …

In this study, we sought to create a database summarizing the expression of human
endogenous retroviruses (HERVs) in various human cancers. HERVs are suitable …

Background The protein “human endogenous retrovirus H long terminal repeat-associating
2”(HHLA2), a member of the B7 family, has been linked to cancer progression and immune …

Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2) is a newly
emerging immune checkpoint that belongs to B7 family. HHLA2 has a co-stimulatory …

Background The B7 protein family is one of the most important immune checkpoint proteins.
Gastric cancer (GC) is the fourth most common cause of cancer‐related mortality worldwide …

Cancer immunotherapy enhances the body's immunity against tumors by mitigating immune
escape. Compared with traditional chemotherapy, immunotherapy has the advantages of …

Cancer immunotherapy is a rapidly developing field of medicine that aims to use the host's
immune mechanisms to inhibit and eliminate cancer cells. Antibodies targeting CTLA-4, PD …

Background: Colorectal carcinoma (CRC) is the third most common malignancy worldwide.
Human endogenous retrovirus H long terminal repeat-associating protein 2 (HHLA2) is a …