Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

VEXAS syndrome (vacuoles in myeloid progenitors, E1 ubiquitin activating enzyme, X-
linked, autoinflammatory manifestations and somatic) is an autoinflammatory condition …

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …

As efficacy and safety data emerge, differences between JAK inhibitor subclasses are
appearing. JAK1 selective drugs, upadacitinib and filgotinib, have broadly come with the …

Background Janus kinase (JAK)‐mediated cytokine signalling contributes to local and
systemic inflammation in hidradenitis suppurativa (HS). Objectives To describe the safety …

Asthma is an inflammatory disease of the airways characterized by intermittent episodes of
wheezing, chest tightness, and cough. Many of the inflammatory pathways implicated in …

Importance The risk of venous thromboembolism (VTE) among patients with atopic
dermatitis (AD), especially when receiving treatment with Janus kinase (JAK) inhibitors, is …

Numerous chronic inflammatory skin diseases are associated with the release of
proinflammatory cytokines, which act via the intracellular JAK‐STAT pathway. JAK inhibitors …

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition of the
gastrointestinal tract that requires chronic treatment and strict surveillance. Development of …