Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

Over the past fifteen years, we have unveiled a new mechanism by which cells achieve
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …

Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency
through compartmentalizing DNPS enzymes during stressed conditions. However, the …

While it is well known that expression levels of metabolic enzymes regulate the metabolic
state of the cell, there is mounting evidence that the converse is also true, that metabolite …

Purines are ancient metabolites with established and emerging metabolic and non-
metabolic signaling attributes. The expression of purine metabolism-related genes is …

In this study, we advance our understanding of the spatial relationship between the
purinosome, a liquid condensate consisting of six enzymes involved in de novo purine …

The cellular defense against viruses involves the assembly of oligomers, granules and
membraneless organelles (MLOs) that govern the activation of several arms of the innate …

Purine nucleotides, generated by de novo synthesis and salvage pathways, are essential for
metabolism and act as building blocks of genetic material. To avoid an imbalance in the …

In human cells, de novo purine nucleotide biosynthesis is known to be regulated through the
formation of a metabolon called purinosome. Here, we employed a bacterial two‐hybrid …

Tumor cells are required to undergo metabolic reprogramming for rapid development and
progression, and one of the metabolic characteristics of cancer cells is the excessive …