Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and
non-excitable cell types, offers enormous potential for modulation of important cell functions …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

Introduction Recent evidence suggests that tissue accumulation of senescent p16 INK4a-
positive cells during the life span would be deleterious for tissue functions and could be the …

In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence.
Alternatively, cells enter senescence in response to inappropriate growth signals such as …

Hematopoietic progenitors undergo differentiation while navigating several cell division
cycles, but it is unknown whether these two processes are coupled. We addressed this …

Mitochondrial shape change, brought about by molecules that promote either fission or
fusion between individual mitochondria, has been documented in several model systems …

Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical
regulators of endometrial differentiation, known as decidualization, which is a key step …

Poly (ADP-ribose) polymerase (PARP) 14—a member of the B aggressive lymphoma (BAL)
family of macrodomain-containing PARPs—is an ADP ribosyltransferase that interacts with …

Development of the endocrine compartment of the pancreas, as represented by the islets of
Langerhans, occurs through a series of highly regulated events encompassing branching of …

In somatic cells, the length of the G1 phase of the cell cycle is tightly linked to differentiation,
and its elongation can drive differentiation in many cases. Although it has been suggested …