Disease relapse in cancer patients many years after clinical remission, often referred to as
cancer dormancy, is well documented but remains an incompletely understood …

Quiescent cancer cells (QCCs) are nonproliferating cells arrested in the G0 phase,
characterized by ki67low and p27high. QCCs avoid most chemotherapies, and some …

The ability of the classic tumour‐suppressive let‐7 family to inhibit carcinogenesis, tumour
progression, recurrence and pluripotency of cancer stem cells has generated significant …

Individual cancer cells can switch, reversibly, to a non-proliferative dormant state, a process
characterized by two principal stages:(i) establishment and maintenance, and (ii) the …

Breast cancer is a systemic disease characterized by early dissemination of tumor cells to
distant organs. In this foreign environment, tumor cells may stay in a dormant state as single …

During the past decades, drugs targeting transforming growth factor-β (TGFβ) signaling have
received tremendous attention for late-stage cancer treatment since TGFβ signaling has …

Background Therapy resistance in cancer is often driven by a subpopulation of cells that are
temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose …

Colorectal cancer cells with stem-like properties, referred to as colon cancer–initiating cells
(CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular …

The degree of heterogeneity among cancer stem cells (CSC) remains ill-defined and may
hinder effective anti-CSC therapy. Evaluation of oral cancers for such heterogeneity …

Cancer cells have heterogeneous fitness, and this heterogeneity stems from genetic and
epigenetic sources. Here, we sought to assess the contribution of asymmetric mitosis (AM) …