Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications

MN Mithaiwala, D Santana-Coelho, GA Porter… - Cells, 2021 - mdpi.com
Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …

Mesenchymal stem cell-derived exosomes regulate microglia phenotypes: a promising treatment for acute central nervous system injury

YY Liu, Y Li, L Wang, Y Zhao, R Yuan… - Neural Regeneration …, 2023 - journals.lww.com
There is growing evidence that long-term central nervous system (CNS) inflammation
exacerbates secondary deterioration of brain structures and functions and is one of the …

Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential

J Allen, SS Dames, CJ Foldi, SR Shultz - Molecular Psychiatry, 2024 - nature.com
Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of
disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an …

Environmental enrichment improves traumatic brain injury-induced behavioral phenotype and associated neurodegenerative process

V Tapias, EH Moschonas, CO Bondi, VJ Vozzella… - Experimental …, 2022 - Elsevier
Traumatic brain injury (TBI) causes persistent cognitive impairment and neurodegeneration.
Environmental enrichment (EE) refers to a housing condition that promotes sensory and …

FcRn inhibitors: a novel option for the treatment of myasthenia gravis

LN Zhu, HM Hou, S Wang, S Zhang… - Neural Regeneration …, 2023 - journals.lww.com
Myasthenia gravis is an acquired, humoral immunity-mediated autoimmune disease
characterized by the production of autoantibodies that impair synaptic transmission at the …

Central nervous system injury–induced immune suppression

EA Sribnick, PG Popovich, MW Hall - Neurosurgical focus, 2022 - thejns.org
Central nervous system trauma is a common cause of morbidity and mortality. Additionally,
these injuries frequently occur in younger individuals, leading to lifetime expenses for …

Traumatic brain injury and immunological outcomes: the double-edged killer

S Datta, F Lin, LD Jones, SC Pingle, S Kesari… - Future science …, 2023 - Taylor & Francis
Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide
resulting from falls, car accidents, sports, and blast injuries. TBI is characterized by severe …

Role of citicoline in the management of traumatic brain injury

JJ Secades - Pharmaceuticals, 2021 - mdpi.com
Head injury is among the most devastating types of injury, specifically called Traumatic Brain
Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the …

Proteomics and bioinformatics reveal insights into neuroinflammation in the acute to subacute phases in rat models of spinal cord contusion injury

XQ Yao, ZY Liu, JY Chen, ZC Huang, JH Liu… - The FASEB …, 2021 - Wiley Online Library
Neuroinflammation is recognized as a hallmark of spinal cord injury (SCI). Although
neuroinflammation is an important pathogenic factor that leads to secondary injuries after …

The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …