Haemarthroses cause major morbidity in patients with haemophilia. Blood has devastating
effects on all joint components, resulting in synovitis, osteochondral degeneration and …

Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and
trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and …

Objective To review the current knowledge on bone health in patients with hemophilia A and
the underlying pathogenetic mechanisms. Data Sources Original research articles, meta …

Objective Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is
elevated in the serum and synovial fluid of patients with osteoarthritis (OA). This study was …

Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major
manifestation of the bleeding disorder hemophilia A. HA typically begins with hemophilic …

Hemophilia A is an X-linked hereditary disorder that results from deficient coagulation factor
VIII (FVIII) activity, leading to spontaneous bleeding episodes, particularly in joints and …

Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the
synovial joints. Recurrent joint bleeds induce a cascade of inflammatory as well as …

Wound healing requires interactions between coagulation, inflammation, angiogenesis,
cellular migration, and proliferation. Healing in dermal wounds of hemophilia B mice is …

Objectives Detailed knowledge of the sequential cell and tissue responses following
haemarthrosis is important for a deep understanding of the pathological process initiated …

Introduction The relationship between severe hemophilia and osteoporosis has been well
established in the literature. However, although the importance of its prevention in order to …