Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
WJ Valentine, K Yanagida, H Kawana, N Kono… - Journal of Biological …, 2022 - ASBMB
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
[HTML][HTML] Aging-associated alterations in mammary epithelia and stroma revealed by single-cell RNA sequencing
Aging is closely associated with increased susceptibility to breast cancer, yet there have
been limited systematic studies of aging-induced alterations in the mammary gland. Here …
been limited systematic studies of aging-induced alterations in the mammary gland. Here …
Lysophospholipid acyltransferases orchestrate the compositional diversity of phospholipids
Lysophospholipid acyltransferases (LPLATs), in concert with glycerol-3-phosphate
acyltransferases (GPATs) and phospholipase A 1/2 s, orchestrate the compositional diversity …
acyltransferases (GPATs) and phospholipase A 1/2 s, orchestrate the compositional diversity …
DNA methylation and expression profiles of whole blood in Parkinson's disease
AR Henderson, Q Wang, B Meechoovet… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease. It is presently only accurately diagnosed at an advanced stage by a series of motor …
disease. It is presently only accurately diagnosed at an advanced stage by a series of motor …
Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis
HP Tao, TF Lu, S Li, GX Jia, XN Zhang… - Cellular and Molecular …, 2023 - Springer
Spermatogenesis is a complicated process of germ cell differentiation that occurs within the
seminiferous tubule in the testis. Peritubular myoid cells (PTMCs) produce major …
seminiferous tubule in the testis. Peritubular myoid cells (PTMCs) produce major …
[HTML][HTML] Small intestine-specific knockout of CIDEC improves obesity and hepatic steatosis by inhibiting synthesis of phosphatidic acid
L Huang, Q Liao, T Pan, Y Sun, Z Aluo… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The small intestine is main site of exogenous lipid digestion and absorption, and it is
important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like …
important for lipid metabolic homeostasis. Cell death-inducing DNA fragmentation-factor like …
Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and …
EA Triantafyllou, E Georgatsou, I Mylonis… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Hypoxia inducible factor-1 (HIF-1) supports survival of normal cells under low
oxygen concentration and cancer cells in the hypoxic tumor microenvironment. This involves …
oxygen concentration and cancer cells in the hypoxic tumor microenvironment. This involves …
Differential Methylation Profile in Fragile X Syndrome-Prone Offspring Mice after in Utero Exposure to Lactobacillus Reuteri
RR AlOlaby, M Zafarullah, M Barboza, G Peng… - Genes, 2022 - mdpi.com
Environmental factors such as diet, gut microbiota, and infections have proven to have a
significant role in epigenetic modifications. It is known that epigenetic modifications may …
significant role in epigenetic modifications. It is known that epigenetic modifications may …
The lysophosphatidic acid acyltransferases (acylglycerophosphate acyltransferases) family: one reaction, five enzymes, many roles
RM Bradley, RE Duncan - Current opinion in lipidology, 2018 - journals.lww.com
LPAATs are critical mediators of cell membrane phospholipid synthesis, regulating the
production of specific down-stream glycerophospholipid species through generation of …
production of specific down-stream glycerophospholipid species through generation of …
Biosynthetic enzymes of membrane glycerophospholipid diversity as therapeutic targets for drug development
WJ Valentine, T Hashidate–Yoshida… - Druggable Lipid …, 2020 - Springer
Biophysical properties of membranes are dependent on their glycerophospholipid
compositions. Lysophospholipid acyltransferases (LPLATs) selectively incorporate fatty …
compositions. Lysophospholipid acyltransferases (LPLATs) selectively incorporate fatty …