Antiretroviral treatment of HIV-2 infection: available drugs, resistance pathways, and promising new compounds
Currently, it is estimated that 1–2 million people worldwide are infected with HIV-2,
accounting for 3–5% of the global burden of HIV. The course of HIV-2 infection is longer …
accounting for 3–5% of the global burden of HIV. The course of HIV-2 infection is longer …
Black-box vs. white-box: Understanding their advantages and weaknesses from a practical point of view
O Loyola-Gonzalez - IEEE access, 2019 - ieeexplore.ieee.org
Nowadays, in the international scientific community of machine learning, there exists an
enormous discussion about the use of black-box models or explainable models; especially …
enormous discussion about the use of black-box models or explainable models; especially …
Multi-scale modelling in computational biomedicine
PMA Sloot, AG Hoekstra - Briefings in bioinformatics, 2010 - academic.oup.com
The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-
science systems, bridging a wide range of temporal and spatial scales. This article reviews …
science systems, bridging a wide range of temporal and spatial scales. This article reviews …
QSPR estimation of the auto-ignition temperature for pure hydrocarbons
TNG Borhani, A Afzali, M Bagheri - Process Safety and Environmental …, 2016 - Elsevier
Due to the combustible nature of hydrocarbons, accurate safety information for their safe
utilization and transport is essential. The autoignition temperature (AIT) is an important …
utilization and transport is essential. The autoignition temperature (AIT) is an important …
A genotypic assay for the amplification and sequencing of integrase from diverse HIV-1 group M subtypes
K Van Laethem, Y Schrooten, K Covens… - Journal of virological …, 2008 - Elsevier
Recently, the Food and Drug Administration (FDA) of the USA approved the first integrase
inhibitor for inclusion in treatment regimens of HIV-1 patients failing their current regimens …
inhibitor for inclusion in treatment regimens of HIV-1 patients failing their current regimens …
Predicting human immunodeficiency virus inhibitors using multi-dimensional Bayesian network classifiers
OBJECTIVE: Our aim is to use multi-dimensional Bayesian network classifiers in order to
predict the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and protease …
predict the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and protease …
HIV decision support: from molecule to man
Human immunodeficiency virus (HIV) is recognized to be one of the most destructive
pandemics in recorded history. Effective highly active antiretroviral therapy and the …
pandemics in recorded history. Effective highly active antiretroviral therapy and the …
A multifaceted analysis of HIV-1 protease multidrug resistance phenotypes
KM Doherty, P Nakka, BM King, SY Rhee… - BMC …, 2011 - Springer
Background Great strides have been made in the effective treatment of HIV-1 with the
development of second-generation protease inhibitors (PIs) that are effective against …
development of second-generation protease inhibitors (PIs) that are effective against …
Molecular modeling of the standard state heat of formation
The standard heat of formation is a basic thermophysical property required in determining
enthalpies of reaction and in thermodynamic stability analyses. Further, the enthalpies of …
enthalpies of reaction and in thermodynamic stability analyses. Further, the enthalpies of …
Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure
AT Dumans, CC Barreto, AF Santos, M Arruda… - Infection, Genetics and …, 2009 - Elsevier
The goal of this work was to compare the differences between human immunodeficiency
virus type 1 (HIV-1) of B and F1 subtypes in the acquisition of major and minor protease …
virus type 1 (HIV-1) of B and F1 subtypes in the acquisition of major and minor protease …