Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia

X Yang, L Ma, X Zhang, L Huang, J Wei - Experimental Hematology & …, 2022 - Springer
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases arising from the bone marrow (BM), and approximately …

The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes

A Raza, N Galili - Nature Reviews Cancer, 2012 - nature.com
Myelodysplastic syndromes (MDS) are malignant clonal disorders of haematopoietic stem
cells and their microenvironment, affecting older individuals (median age∼ 70 years) …

The role of apoptosis, proliferation, and the Bcl-2–related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS

JE Parker, GJ Mufti, F Rasool, A Mijovic… - Blood, The Journal …, 2000 - ashpublications.org
Bone marrow CD34+ cell apoptosis (annexin V), proliferation (Ki-67), and Bcl-2-related
protein expression was evaluated by flow cytometry in 102 patients with myelodysplastic …

Myelodysplastic syndromes

PL Greenberg, NS Young… - ASH Education Program …, 2002 - ashpublications.org
The myelodysplastic syndromes (MDS) are characterized by hemopoietic insufficiency
associated with cytopenias leading to serious morbidity plus the additional risk of leukemic …

IL‐17‐producing CD4+ T cells, pro‐inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome

SY Kordasti, B Afzali, Z Lim, W Ingram… - British journal of …, 2009 - Wiley Online Library
Immunological responses are increasingly recognised as being important in the initiation
and progression of myelodysplastic syndrome (MDS). Indeed, autoimmune diseases …

The myelodysplastic syndrome (s): a perspective and review highlighting current controversies

DP Steensma, A Tefferi - Leukemia research, 2003 - Elsevier
The myelodysplastic syndrome (MDS) includes a diverse group of clonal and potentially
malignant bone marrow disorders characterized by ineffective and inadequate …

Opportunities for Trisenox®(arsenic trioxide) in the treatment of myelodysplastic syndromes

A List, M Beran, J DiPersio, J Slack, N Vey… - Leukemia, 2003 - nature.com
Arsenic trioxide (ATO) has a long history of efficacy as an antileukemic agent. However, with
the advent of modern therapy, it had been relegated to a historical footnote. In the 1990s …

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors

TA Navas, M Mohindru, M Estes, JY Ma, L Sokol… - Blood, 2006 - ashpublications.org
The myelodysplastic syndromes (MDSs) are collections of heterogeneous hematologic
diseases characterized by refractory cytopenias as a result of ineffective hematopoiesis …

Pathobiology, classification, and diagnosis of myelodysplastic syndrome

GJ Mufti - Best Practice & Research Clinical Haematology, 2004 - Elsevier
Recent advances in molecular genetics have advanced the knowledge regarding the
mechanisms leading to myelodysplastic syndrome (MDS), secondary acute myeloid …

Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes

M Sawanobori, S Yamaguchi, M Hasegawa, M Inoue… - Leukemia research, 2003 - Elsevier
Myelodysplastic syndromes (MDS) are characterized by peripheral blood cytopenias despite
hypercellularity of the bone marrow regarded as the result of ineffective hematopoiesis …