Therapeutic efficacy of natural product 'C-phycocyanin'in alleviating streptozotocin-induced diabetes via the inhibition of glycation reaction in rats

A Husain, S Alouffi, A Khanam, R Akasha… - International Journal of …, 2022 - mdpi.com
Diabetes is a long-term metabolic disorder characterized by persistently elevated blood
sugar levels. Chronic hyperglycemia enhances glucose–protein interactions, leading to the …

An insight into the pathogenesis of diabetic cardiomyopathy along with the novel potential therapeutic approaches

H Vig, R AP, HN Vishwas, S Tyagi… - Current Diabetes …, 2024 - ingentaconnect.com
Background: The existence of aberrant myocardial activity and function in the exclusion of
those other cardiovascular events, such as atherosclerosis, hypertension, and severe valve …

D-ribose-mediated glycation of fibrinogen: role in the induction of adaptive immune response

S Alouffi, A Khanam, A Husain, R Akasha… - Chemico-Biological …, 2022 - Elsevier
A nonenzymatic reaction between reducing sugars and amino groups of proteins results in
the formation of advanced glycation end products, which are linked to a number of chronic …

C-phycocyanin from cyanobacteria: a therapeutic journey from antioxidant defence to diabetes management and beyond

A Husain, A Khanam, S Alouffi, U Shahab… - Phytochemistry …, 2024 - Springer
Diabetes mellitus (DM) is a rapidly growing global epidemic, particularly type 2 diabetes
mellitus (T2DM), which accounts for 90% of cases. Despite the availability of various …

Generation of autoantibodies against glycated fibrinogen: Role in diabetic nephropathy and retinopathy

A Khanam, S Alouffi, AR Alyahyawi, A Husain… - Analytical …, 2024 - Elsevier
The process of glycation, characterized by the non-enzymatic reaction between sugars and
free amino groups on biomolecules, is a key contributor to the development and progression …

A perspective on the impact of advanced glycation end products in the progression of diabetic nephropathy

A Khanam, S Ahmad, A Husain - Current Protein and Peptide …, 2023 - ingentaconnect.com
In 2007, diabetes affected around 244 million people across the globe. The number of
diabetics worldwide is projected to reach 370 million by 2030. With diabetes incidence …

Antiglycation potential of plant based TiO2 nanoparticle in D‐ribose glycated BSA in vitro

F Alenazi, M Saleem, AS Syed Khaja… - Cell Biochemistry …, 2022 - Wiley Online Library
Biosynthetic procedure is one of the best alternatives, inexpensive and ecologically sound
for the synthesis of titanium dioxide (TiO2) nanoparticles using a methanolic extract of …

[HTML][HTML] In-silico exploration of cyanobacterial bioactive compounds for managing diabetes: Targeting alpha-amylase and beta-glucosidase

A Khanam, KM Kavita, RK Sharma, A Farooqui… - Intelligent …, 2023 - Elsevier
This research investigates the potential of bioactive compounds derived from cyanobacteria
as inhibitors of alpha-amylase and beta-glucosidase enzymes, which are involved in starch …

From Pond Scum to Miracle Molecules: Cyanobacterial Compounds New Frontiers

A Husain, M Nematullah, H Khan… - European Journal of …, 2024 - dergipark.org.tr
Cyanobacteria are a diverse group of photosynthetic microorganisms known for their
production of bioactive compounds with various biological activities. This review explores …

[HTML][HTML] From Pond Scum to Miracle Molecules: Cyanobacterial Compounds New Frontiers

H Arbab, N Md, K Hamda, S Ravi… - … Journal of Biology, 2024 - iupress.istanbul.edu.tr
Cyanobacteria are a diverse group of photosynthetic microorganisms known for their
production of bioactive compounds with various biological activities. This review explores …