Role of DNA Double-Strand Break Formation in Gyrase Inhibitor-Mediated Killing of Nonreplicating Persistent Mycobacterium tuberculosis in Caseum
P Ashwath, P Osiecki, D Weiner, LE Via… - ACS Infectious …, 2024 - ACS Publications
Tuberculosis is the leading cause of mortality by infectious agents worldwide. The necrotic
debris, known as caseum, which accumulates in the center of pulmonary lesions and …
debris, known as caseum, which accumulates in the center of pulmonary lesions and …
Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies
The SARS-CoV-2 pandemic at the end of 2019 had major worldwide health and economic
consequences. Until effective vaccination approaches were created, the healthcare sectors …
consequences. Until effective vaccination approaches were created, the healthcare sectors …
Exploration of crystal structure, supramolecular organization, and computational studies of a novel pyrazole derivative: A structural and theoretical perspectives
An eminent challenge in contemporary medicine and pharmacy is the identification of
powerful, biologically active, and benign anti-COVID drugs. The objective of this work is to …
powerful, biologically active, and benign anti-COVID drugs. The objective of this work is to …
Rational design and synthesis of novel phenyltriazole derivatives targeting MRSA cell wall biosynthesis
MM Elsebaei, HG Ezzat, AM Helal, MH El-Shershaby… - RSC …, 2024 - pubs.rsc.org
Antimicrobial resistance in methicillin-resistant Staphylococcus aureus (MRSA) is a major
global health challenge. This study reports the design and synthesis of novel phenyltriazole …
global health challenge. This study reports the design and synthesis of novel phenyltriazole …
Prominent antidiabetic and anticancer investigation of Scrophularia deserti extract: Integration of experimental and computational approaches
Diabetes mellitus (DM) is a group of syndromes and complications characterized by
hyperglycemia, metabolic disorders in lipids, carbohydrates, and proteins. It causes an …
hyperglycemia, metabolic disorders in lipids, carbohydrates, and proteins. It causes an …
Hemisynthesis of monoterpene-containing pyridin-2-one, pyrano [2, 3-c] pyrazole and dicarbamate derivatives: in vitro and in silico anti-inflammatory activity
Abstract New monoterpene-containing pyridin-2-one, pyrano [2, 3-c] pyrazole and
dicarbamate derivatives were hemisynthetized from the essential oils of four medicinal …
dicarbamate derivatives were hemisynthetized from the essential oils of four medicinal …
New spiro-heterocyclic coumarin derivatives as antibacterial agents: design, synthesis and molecular docking
AF Al-burgus, AF Ali, OY Al-abbasy - Chimica Techno Acta. 2024. Vol. 11 …, 2024 - elar.urfu.ru
Coumarin derivatives were synthesized herein from 3-acetyl coumarin and 4-(pyrimidin-2-
yldiazenyl) antipyrine, leading to the azo chalcone intermediate compound. The final spiro …
yldiazenyl) antipyrine, leading to the azo chalcone intermediate compound. The final spiro …