Antibacterial pyrazoles: Tackling resistant bacteria

MA Alam - Future Medicinal Chemistry, 2022 - Taylor & Francis
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine,
food production and ultimately life expectancy. Antibiotic resistance is a global concern …

New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies

IMM Othman, ZM Alamshany, NY Tashkandi… - Bioorganic …, 2021 - Elsevier
This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …

Green synthesis of pyrazoles: Recent developments in aqueous methods

S Singh, S Yadav, M Minakshi, R Pundeer - SynOpen, 2023 - thieme-connect.com
Organic syntheses by adopting green protocols such as sonochemical procedures,
microwave technologies, solvent-free conditions, green solvents, heterogeneous catalysis …

Ultrasound-assisted synthesis of 1, 5-disubstituted pyrazoles via HFIP-mediated cascade cyclization of enaminones with aryl hydrazine

S Roy, R Chatterjee, P Kisan, R Dandela - Tetrahedron Letters, 2024 - Elsevier
A simple and efficient metal-free strategy has been developed for the synthesis of 1, 5-
disubstituted pyrazole derivatives by using 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP) …

[HTML][HTML] Novel regioselective synthesis of 1, 3, 4, 5-tetrasubstituted pyrazoles and biochemical valuation on F1FO-ATPase and mitochondrial permeability transition …

V Algieri, C Algieri, P Costanzo, G Fiorani, A Jiritano… - Pharmaceutics, 2023 - mdpi.com
An efficient, eco-compatible, and very cheap method for the construction of fully substituted
pyrazoles (Pzs) via eliminative nitrilimine-alkene 1, 3-dipolar cycloaddition (ENAC) reaction …

Synthesis, characterization, quantum chemical modelling, molecular docking, in silico and in vitro assessment of 3-(2-bromo-5-fluorophenyl))-1-(thiophen-2-yl) prop-2 …

CS Yadav, I Azad, M Nasibullah, N Ahmad… - Scientific Reports, 2024 - nature.com
Abstract α, β-unsaturated carbonyl compounds have extensive applications in various fields,
such as organic, inorganic, analytical, and biological. In the modern era, they offer excellent …

Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR‐Targeted Anticancer Agents

KR Hosamani, HK, R Pal, GSP Matada… - Chemistry & …, 2024 - Wiley Online Library
Pyrazole and its derivatives remain popular heterocycles in drug research, design, and
development. Several drugs include the pyrazole scaffold, such as ramifenazone …

Molecular modeling and antimicrobial activity of newly synthesized benzothiazole-thiazole conjugates

A Alharbi, M Alsahag, A Alisaac… - … of Photochemistry and …, 2024 - Elsevier
Abstract The benzothiazole-thiazole conjugates 4, 5, 6, 7a-c, and 8 were synthesized by
introducing a thiazole moiety into the precursor 2-acetamido-6-(2-cyanoacetyl) …

Structural and antimicrobial activity studies of brand new benzothiazole-pyrazole conjugates

A Bayazeed, H Alharbi, AI Alalawy… - Journal of Molecular …, 2025 - Elsevier
The targeted benzothiazole-pyrazole conjugates 4, 6, 8, 9, and 10 were synthesized through
introducing the pyrazole moiety to the precursor 2-acetamido-6-(2-cyanoacetyl) …

A new polyazomethine-based pyrazole moiety and its reinforced nanocomposites@ ZnO for antimicrobial applications

AA Hakami, HS Alorfi, TA Farghaly… - Designed Monomers …, 2024 - Taylor & Francis
ABSTRACT A new class of biologically active polyazomethine/pyrazole and their related
nanocomposites, polyazomethine/pyrazole/zinc oxide nanoparticles, have been …