In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

While the unique physicochemical properties of nanomaterials that enable regulation of
nanozyme activities are demonstrated in many systems, quantitative relationships between …

The emergence of robust methods to expand the genetic code allows incorporation of non-
canonical amino acids into the polypeptide chain of proteins, thus making it possible to …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

We report a method for the electrochemical deuteration of α, β‐unsaturated carbonyl
compounds under catalyst‐and external‐reductant‐free conditions, with deuteration rates as …

The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …