Wnt signaling controls cell specification and fate during development and adult tissue
homeostasis by converging on a small family of DNA binding factors, the T-cell …

Abstract Sin3 associated protein 18 (SAP18) is an evolutionary conserved protein, originally
discovered in a complex with the transcriptional regulatory protein, Sin3. Subsequent …

We used DNA microarrays to characterize the global gene expression patterns in surface
epithelial cancers of the ovary. We identified groups of genes that distinguished the clear …

The spliceosomal B complex is the substrate that undergoes catalytic activation leading to
catalysis of pre-mRNA splicing. Previous characterization of this complex was performed in …

The deposition of proteins onto newly spliced mRNAs has far reaching consequences for
their subsequent metabolism. We affinity-purified spliced human mRNPs under …

Mutations in Matrin 3 have recently been linked to ALS, though the mechanism that induces
disease in these patients is unknown. To define the protein interactome of wild-type and ALS …

Human RNPS1 was originally purified and characterized as a pre-mRNA splicing activator,
and its role in the postsplicing process has also been proposed recently. To search for …

Previous compositional studies of pre-mRNA processing complexes have been performed
in vitro on synthetic pre-mRNAs containing a single intron. To provide a more …

Heterogeneous nuclear ribonucleoprotein‐M (hnRNP‐M) is an abundant nuclear protein
that binds to pre‐mRNA and is a component of the spliceosome complex. A direct interaction …

Cyclin D1 expression represents one of the key mitogen-regulated events during the G1
phase of the cell cycle, whereas Cyclin D1 overexpression is frequently associated with …