Aberrant proteostasis is thought to be involved in the pathogenesis of neurodegenerative
diseases. Some proteostasis abnormalities are ameliorated by chaperones. Chaperones …

The mechanism that maintains ER-to-Golgi vesicles formation and transport is complicated.
As one of the adapters, Ninein-like protein (Nlp) participated in assembly and transporting of …

PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell
surface, leading to decreased hepatic clearance of LDL particles and increased levels of …

Protein secretion is an essential process that drives cell growth and communication.
Enrichment of soluble secretory proteins into ER-derived transport carriers occurs via …

Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring
and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic …

Numerous trafficking and quality control pathways evolved to handle the diversity of proteins
made by eukaryotic cells. However, at every step along the biosynthetic pathway, there is …

Objective Lipoprotein assembly and secretion in the small intestine are critical for dietary fat
absorption. Surfeit locus protein 4 (SURF4) serves as a cargo receptor, facilitating the …

The biosynthetic secretory pathway is comprised of multiple steps, modifications and
interactions that form a highly precise pathway of protein trafficking and secretion, that is …

Proteins that are destined to enter the secretory pathway are synthesized on the rough
endoplasmic reticulum (ER) and then translocated into the ER lumen, where they undergo …

Recently, we demonstrated that agonist-stimulated Ca 2+ signaling involving IP3 receptors
modulates ER export rates through activation of the penta-EF Hand proteins apoptosis …