The broad-based legalization of cannabis use has created a strong need to understand its
impact on human health and behavior. The risks that may be associated with cannabis use …

A multitude of roles for the endogenous cannabinoid system has been proposed by recent
research efforts. A large number of endogenous cannabinoid neurotransmitters or …

Truly global in scope and with contributions from leading researchers around the world, The
Handbook of Cannabis is the definitive resource on this fascinating drug. Combining …

Abstract Δ9-Tetrahydrocannabinol (THC), the primary psychoactive constituent of marijuana,
is rapidly transferred from lungs to blood during smoking. Oxidative metabolism of THC …

Delta‐9‐tetrahydrocannabinol (THC) was given intravenously, by smoking, and by mouth to
11 healthy subjects. Plasma profiles of THC after smoking and intravenous injection were …

Increasing interest in the biology, chemistry, pharmacology, and toxicology of cannabinoids
and in the development of cannabinoid medications necessitates an understanding of …

Materials and Methods Chemical and reagents. 11-[“C] A"-THC (batch DW-V11-153, 107
pCi/mg) and unlabeled, pyrogen-free THC were supplied by the Na-tional Institute on Drug …

Delta‐9‐tetrahydrocannabinol (Δ‐9‐THC) is the main psychoactive ingredient of cannabis
(marijuana). The present review focuses on the pharmacokinetics of THC, but also includes …

Deuterium labelled Δ1‐tetrahydrocannabinol was administered intravenously (5.0 mg) and
by smoking (10.0 mg) to five heavy and four light marihuana users. All subjects smoked an …

The number of lipophilic drug candidates in pharmaceutical discovery pipelines has
increased in recent years. These drugs often possess physicochemical properties that result …