Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene
expression that systematically removes non-coding regions (introns) and ligates coding …

Patients with cholestatic liver disease, including those with primary biliary cholangitis, can
experience symptoms of impaired cognition or brain fog. This phenomenon remains …

Cellular senescence is not only associated with ageing but also impacts physiological and
pathological processes, such as embryonic development and wound healing. Factors …

As bisphenol A (BPA) effortlessly crosses the blood-brain barrier, its serious impacts on the
neuronal microenvironment towards precocious induction of oxidative stress and …

Changes in hTERT splice variant expression have been proposed to facilitate the decrease
of telomerase activity during fetal development in various human tissues. Here, we analyzed …

Alternative splicing was found to be a common phenomenon after the advent of whole
transcriptome analyses or next generation sequencing. Over 90% of human genes were …

A hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic
cause of amyotrophic lateral sclerosis (ALS) and its discovery has revolutionized our …

Cellular senescence is associated with aging but also impacts various physiological and
pathological processes such as embryonic development and wound healing. Factors …

Alternative splicing (AS) is one of the main contributors to transcriptome diversity and
functional complexity involved in the process of neuronal development. Evidence suggests …